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KMID : 0361019960390060946
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Korean Journal of Otolaryngology - Head and Neck Surgery
1996 Volume.39 No. 6 p.946 ~ p.951
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The Effect of Salicylate-Ralated Unknown Compound on Hearing in Guinea Pig
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Abstract
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cylate is well-known to produce a reversible hearing loss and tinnitus. However, the mechanism of salicylate ototoxicity remain unresolved yet.
Previous studies suggested that the increase of unknown compound concentration in perilymph of guinea pig might be important for the mechanism of salicylate ototoxicity. So we tried to compare the effect of undnown compound with that of sodium
salicylate on electrocochleographic changes.
Using guinea pigs as experimental animals, sodium salicylate(460㎎/㎏) was injected intraperitoneally and unknown compound(5㎕) was applied on round window membrane. Threshold of compound action potential(CAP) was determined at different time
intevals.
The loss of 30dBHL maximum CAP threshold was observed in 4 hours after intraperitoneal injection of sodium salicylate and the hearing was recovered to normal threshold in 24 hours. In another experimental group, maximum CAP threshold loss was
21dBHL at
6 hours after applying of unknown compound on the round window membrane and the hearing was partially recovered in 24 hours. In the control groups, hearing threshold was changed within 67dBHL. This results suggested that unknown compound might be
an
important component inducing salicylate ototoxicity. (Korean J Otolaryngl1 39 : 6, 1996)
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